刘国生研究员围绕过渡金属催化 C-H 键的活化和 C-F 键的形成这两个研究热点和难点，对烯烃的直接选择性官能化开展了系统的研究工作，研究兴趣包括过渡金属催化烯烃、炔烃及芳烃的氟化，金属有机催化形成 C-F 键的机理研究，过渡金属催化下使用 O₂ 和 H₂O₂ 为氧化剂对烯烃和芳烃进行氧化官能化，氟化杂环芳烃的合成研究。

• 2007.07-至今中科院上海有机所研究员
• 2005.08-2007.07美国威斯康辛大学麦迪逊分校化学系，研究助理
• 2003.03-2005.07美国Lehigh 大学，博士后
• 1999.09-2002.08中科院上海有机化学研究所，获理学博士
• 1996.09-1999.08中科院大连化学物理研究所，获理学硕士
• 1991.09-1995.07南京理工大学化工学院，获工学学士

近期代表性成果：

• Enantioselective Copper-Catalyzed Radical Cyanation of Propargylic C-H Bonds: Easy Access to Chiral Allenyl Nitriles.
• Ronghua Lu#, Tilong Yang#, Xin Chen, Wenzheng Fan, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* J. Am. Chem. Soc., 2021, 143, 14451-14457.
• Asymmetric Palladium-Catalyzed Oxycarbonylation of Terminal Alkenes: Efficient Access to β-Hydroxy Alkylcarboxylic Acids.
• Bing Tian, Xiang Li, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed., 2021, 60, 14881-14886.
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• Anionic Bisoxazoline Ligands Enable Copper-Catalyzed Asymmetric Radical Azidation of Acrylamides.
• Lianqian Wu,# Zhihan Zhang,# Dunqi Wu,# Fei Wang, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Angew. Chem. Int. Ed., 2021, 60, 6997-7001. (# These author contributed equally to this work).
• Palladium-Catalysed Enantioselective Diacetoxylation of Terminal Alkenes.
• Bing Tian, Pinhong Chen , Xuebing Leng, Guosheng Liu* Nat. Catal., 2021, 4, 172-179.
• Ligand-Controlled Regioselective Pd-Catalyzed Diamination of Alkenes.
• Xiaojian Liu, Chuanqi Hou, Yiyuan Peng,* Pinhong Chen,* Guosheng Liu* Org. Lett., 2020, 22, 9371-9375.
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• Palladium(II)-Catalyzed Enantioselective Azidation of Unactivated Alkenes.
• Xiaonan Li, Xiaoxu Qi, Chuanqi Hou, Pinhong Chen,* Guosheng Liu* Angew. Chem. Int. Ed., 2020, 59, 17239-17244.
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• Enantioselective Copper-Catalyzed Alkynylation of Benzylic C-H Bonds via Radical Relay.
• Liang Fu, Zhihan Zhang, Pinhong Chen, Zhenyang Lin*, Guosheng Liu* J. Am. Chem. Soc., 2020, 142, 28, 12493-12500.
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• Enantioselective Palladium(II)-Catalyzed Oxidative Aminofluorination of Unactivated Alkenes with Et4NF·3HF as a Fluoride Source.
• Chuanqi Hou, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed., 2020, 59, 2735-2739.
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• Site-specific Allylic C-H Bond Functionalization with a Copper-Bound N-Centred Radical.
• Jiayuan Li, Zhihan Zhang, Lianqian Wu, Wen Zhang, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Nature, 2019, 574, 516-521.
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• Palladium(II)-Catalyzed Enantioselective Aminotrifluoromethoxylation of Unactivated Alkenes using CsOCF3 as a Trifluoromethoxide Source.
• Chaohuang Chen, Philipp Miro Pflüger, Pinhong Chen, Guosheng Liu* Angew. Chem. Int. Ed., 2019, 58, 2392-2396.
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• Enantioselective Pd(II)-Catalyzed Intramolecular Oxidative 6-endo Aminoacetoxylation of Unactivated Alkenes.
• Xiaoxu Qi, Chaohuang Chen, Chuanqi Hou, Liang Fu, Pinhong Chen, Guosheng Liu* J. Am. Chem. Soc., 2018, 140, 7415−7419.
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• Divergent Synthesis of CF3-Substituted Allenyl Nitriles by Ligand-Controlled Radical 1,2- and 1,4-Addition to 1,3-Enynes.
• Fei Wang, Dinghai Wang, Yu Zhou, Ling Liang, Ronghua Lu, Pinhong Chen, Zhenyang Lin,* Guosheng Liu* Angew. Chem. Int. Ed., 2018, 57, 7140-7145.
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• Enantioselective cyanation of benzylic C-H bonds via copper-catalyzed radical relay
• Wen Zhang,# Fei Wang,# Scott D. McCann, Dinghai Wang, Pinhong Chen, Shannon S. Stahl,* Guosheng Liu* Science, 2016, 353, 1014-1018.（# These author contributed equally to this work) # Free access to this paper#
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