研究领域为金属化学生物学。主要研究包括生物无机传感与成像、金属抗肿瘤药物的分子作用机制与靶向输运等。

金属离子在生命信号传递过程中发挥着不可替代的作用，金属离子信号物种的变异常与多种疾病相关。因此，活体条件下各种金属信号物种的特异识别与可视化研究成为化学生物学领域一个前沿热点。我们关注的主要物种包括金属离子、无机信号分子以及金属药物物种等。

以顺铂为代表的金属抗肿瘤药物在临床中广泛使用，但毒性、抗药性等问题影响了这类药物的进一步应用。课题组长期从事金属药物相关研究，通过化学生物学策略，在顺铂类药物的作用机制及其靶向输运、新型单功能铂类抗肿瘤配合物的设计等。

• 2006-2014任化学化工学院院长
• 2000-2010任配位化学国家重点实验室主任
• 1999-至今南京大学教授
• 1996.09-1999.05英国爱丁堡大学，研究助理
• 1996.06-1996.10加拿大不列颠哥伦比亚大学，访问学者
• 1994.09-1996.06英国伦敦大学，博士后
• 1989.11-1994意大利帕多瓦大学学习，获博士学位

近期代表性成果

Recent Reviews:

• X.H. Wang, X.Y. Wang, S.X. Jin, N. Muhammad, Z.J. Guo, Stimuli-Responsive Therapeutic Metallodrugs, Chem. Rev., 2019, 119, 1138-1192.
• Y.C. Chen, Y. Bai, Z. Han, W.J. He, Z.J. Guo, Photoluminescence imaging of Zn²⁺ in living systems, Chem. Soc. Rev., 2015, 44, 4517-4546.
• X.Y. Wang, X.H. Wang, Z.J. Guo,Functionalization of Platinum Complexes for Biomedical Applications, Acc. Chem. Res., 2015, 48, 2622−2631.
• N. Muhammad, Z.J. Guo, Metal-based anticancer chemotherapeutic agents, Curr. Opin. Chem. Biol., 2014, 19, 144-153.
• Z.P. Liu, W.J. He, Z.J. Guo, Metal coordination in photoluminescent sensing, Chem. Soc. Rev., 2013, 42, 1568-1600.
• X.Y. Wang, Z.J. Guo, Targeting and delivery of platinum-based anticancer drugs, Chem. Soc. Rev., 2013, 42, 202-224.

Recent Research Articles:

• Z.Y. Chen, X.L. Mu, Z. Han, S.P. Yang, C.L. Zhang, Z.J. Guo, Y. Bai, W.J. He, An Optical/Photoacoustic Dual-Modality Probe: Ratiometric in/ex Vivo Imaging for Stimulated H2S Upregulation in Mice, J. Am. Chem. Soc., 2019, 141, 17973−17977.
• X.L. Xue, C.G. Qian, H.B. Fang, H.K. Liu, H. Yuan, Z.J. Guo, Y. Bai, W.J. He, Photoactivated Lysosomal Escape of a Monofunctional Pt-II Complex Pt-BDPA for Nucleus Access, Angew. Chem. Int. Ed., 2019, 58, 12661-12666.
• Z.Z. Zhu, Z.H. Wang, C.L. Zhang, Y.J. Wang, H.M. Zhang, Z.J. Gan, Z.J. Guo, X.Y. Wang, Mitochondrion-targeted platinum complexes suppressing lung cancer through multiple pathways involving energy metabolism, Chem. Sci., 2019, 10, 3089-3095.
• K. Wang, C.C. Zhu, Y.F. He, Z.Q. Zhang, W. Zhou, N. Muhammad, Y. Guo, X.Y. Wang, Z.J. Guo, Restraining Cancer Cells by Dual MetabolicInhibition with aMitochondrion-Targeted Platinum(II) Complex, Angew. Chem. Int. Ed., 2019, 58, 4638-4643.
• Z.Z. Zhu, Z.H. Wang, Y.G. Hao, C.C. Zhu, Y. Jiao, H.C. Chen, Y.M. Wang, J. Yan, Z.J. Guo, X.Y. Wang, Glutathione boosting the cytotoxicity of a magnetic platinum(IV) nano-prodrug in tumor cells, Chem. Sci., 2016, 7, 2864–2869.
• H.C. Chen, J.W. Tian, W.J. He, Z.J. Guo, H₂O₂ Activatable and O₂ Evolving Nanoparticles for Highly Efficient and Selective Photodynamic Therapy against Hypoxic Tumor Cells, J. Am. Chem. Soc., 2015, 137, 1539-1547.
• Z.Z. Zhu, X.Y. Wang, T.J. Li, S. Aime, P.J. Sadler, Z.J Guo, Platinum(II)–Gadolinium(III) Complexes as Potential Single-Molecular Theranostic Agents for Cancer Treatment, Angew. Chem. Int. Ed., 2014, 53, 13225-13228.